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Blood Journal Article by LSBC Scientist Demonstrates that Bone Marrow Stem Cells Can Be Expanded Quantitatively In Vitro

VACAVILLE, Calif.--(BUSINESS WIRE)--Dec. 15, 2002--For the first time, scientists have shown that bone marrow stem cells can be expanded quantitatively in a laboratory. John P. Chute, MD of Large Scale Biology Corporation (Nasdaq:LSBC), is corresponding author of a peer-reviewed article entitled "Ex vivo culture with human brain endothelial cells increases the SCID-repopulating capacity of adult human bone marrow," published today in Blood, the journal of the American Society of Hematology.

The article reports a novel culture method utilizing human brain endothelial cells for which data in mice studies demonstrate a unique hematopoietic activity that increases the repopulating capacity of adult human bone marrow. It is expected that development of such in vitro culture methods to promote expansion of adult human bone marrow will have direct applications in clinical gene therapy and stem cell transplantation.

The work was supported by grants and agreements between the U.S. Office of Naval Research, the Naval Medical Research Center, the National Institutes of Health and LSBC. Dr. Chute's co-authors are Abha A. Saini, Dennis J. Chute, Mark R. Wells, William B. Clark, David M. Harlan, Jenny Park, Margaret K. Stull, Curt Civin and Thomas A. Davis.

About Large Scale Biology Corporation

Large Scale Biology Corporation (Nasdaq:LSBC) uses its functional genomics, proteomics, and biomanufacturing technologies to develop and manufacture personalized drugs, vaccines and diagnostics for rapid identification and effective treatment of disease. Corporate offices and the Research and Pharmaceutical Development divisions are headquartered in Vacaville, Calif.; the Proteomics Division is located in Germantown, Md.; and the Biomanufacturing Division is located in Owensboro, Ky. For more information about Large Scale Biology Corporation, visit the Company's website at www.lsbc.com.

This release contains a forward-looking statement about the potential application of research we are engaged in. We must complete more testing and development and we cannot predict the results of such work. You should not place undue reliance on this forward-looking statement. For a further list and description of risks and uncertainties we face, see the reports filed by Large Scale Biology Corporation with the SEC, including our reports on Forms 10-K and 10-Q. Except as required by law, we do not undertake to update or revise this forward-looking statement, whether as a result of new information, future events or otherwise.

LSBC(TM) is a trademark of Large Scale Biology Corporation.

CONTACT:

Large Scale Biology Corporation

Daniel J. Moriarty, 707/446-5501 ext. 347 (VP, Corporate

Affairs)

dan.moriarty@lsbc.com

Carol Higgins, 707/446-5501 ext. 308 (Corporate Affairs)

SOURCE: Large Scale Biology Corporation

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