Expansionary Institute

Univ. of Texas Scientists Solder Nerve Cells to Semiconductors!! (with PHOTO)(Cybergenesis),

Semiconductors get on our nerves

Nerve cells soldered to semiconductors cross computing with neuroscience.

14 November 2001

Philip Ball

Scientists in the United States are soldering nerve cells to semiconductors. Christine Schmidt and colleagues from the University of Texas at Austin use a sliver of protein to connect neurons and tiny crystals of semiconductors called quantum dots1.

This cross between biology and electronics could have useful applications, including the manufacture of prosthetics operated directly by a user's nerve impulses, and sensors that detect tiny quantities of neurotoxins. It could also help to study how real brains work.

Whether the hybrid heralds a biological computer, a kind of synthetic brain, remains to be seen. It is far from clear whether neurons are any better at computing than the components that are currently used in microelectronic circuitry

Neurons and electronic logic devices communicate by sending and receiving electrical pulses. The details are different, but neurons can be controlled electronically and neurons can themselves trigger electronic circuits. Researchers have already grown artificial circuits from neurons on silicon chips to monitor nerve activity electronically.

But it is hard to get a smooth dialogue going between neurons and semiconductors. Nerve cells tend to grow over every surface in sight, like lichen over stone, but they don't stick very closely. The gap they leave produces a poor electrical contact.

Schmidt's team creates specific, intimate links between neurons and semiconductors using a small protein fragment. One end of this peptide latches onto a nerve cell's surface; the other sticks to the surface of the semiconductor. Being small, the peptide holds the two surfaces closely together.

One end of the peptide contains a chemical hook that snags a particular protein, called an integrin, that is present on the surface of human neurons. Peptides without this hook don't attach to nerve cells. At the other end, a sulphur-containing chemical group bonds to the semiconductor cadmium sulphide.

Using these peptides, the researchers stud the surface of a neuron with tiny 'nanocrystals' of cadmium sulphide, just three millionths of a millimetre (three nanometres) across. The nanocrystal-decorated cell is easy to see under the microscope because the crystals, also known as quantum dots, are fluorescent.

Peptides could help chips cling to nerve cells

Wed Nov 14